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The Earth Shall Blossom: Shaker Herbs And Gardening Structure of the IGF-
binding domain of the
insulin-like growth factor-binding protein-5 (IGFBP-5). IGF2R is a multifunctional receptor that possesses
binding sites for diverse ligands, including
insulin-like growth factor II (IGF2; 147470), retinoic acid, TGF-beta (TGFB1; 190180), urokinase-type plasminogen activator receptor (UPAR, or PLAUR; 173391), and mannose-6-phosphate (M6P), a modification characteristic of lysosomal enzymes.IGF2R plays major roles in controlling IGF signaling …
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Adipose Tissue Hormones and Cytokines.
Adipose tissue produces and releases a vast array of protein signals including
growth factors, cytokines, chemokines, acute phase
proteins, complement-like factors, and adhesion molecules.
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receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications.
Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity.
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growth factor is generally used to describe a protein or peptide whose function is predominantly, although not exclusively, related to the regulation of target tissue
growth …
insulin-like growth factor i, resistance to, due to increased
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Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation
factor" and its effects were termed "nonsuppressible
insulin-like activity" (NSILA) in the 1970s.IGF-1 is a hormone similar in molecular structure to insulin.It plays an important role in childhood
growth and continues to have ...
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