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Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible
insulin-like activity" (NSILA) in the 1970s.IGF-1 is a hormone similar in
molecular structure to
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Insulin may have originated more than a billion years ago. The
molecular origins
of insulin go at least as far back as the simplest unicellular eukaryotes. Apart from animals,
insulin-like proteins are also known to exist in the Fungi and Protista kingdoms.
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molecular perspective,
cisplatin represents a perfect example of how a small alteration in chemical structure can significantly affect biological activity in target cell (Goodsell, 2006).As illustrated in Fig. 2,
cisplatin, carboplatin and oxaliplatin are composed of doubly charged platinum ion surrounded by four ligands, with the amine ligands on the left forming stronger ...
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