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Colonial Gothic: The Templars (RGG1779) A number sign (#) is used with this entry because of evidence that autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 1 (CADASIL1) is caused by heterozygous mutation in the NOTCH3 gene (600276) on chromosome 19p13. Chabriat et … Signs and symptoms. CADASIL may start with attacks of migraine with aura or subcortical transient ischemic attacks or strokes, or mood disorders between 35 and 55 years of age. The disease progresses to subcortical dementia associated with pseudobulbar palsy and urinary incontinence.. Ischemic strokes are the most frequent presentation of CADASIL, with approximately 85% of symptomatic ... 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